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Comparative genomic framework could revolutionise placenta research

Wednesday, 18 August 2010

A new approach to placenta-specific genes could have major implications for human reproductive health and animal productivity, with potential for some high-impact publications.

Professor Neil Gemmell presented the project on behalf of his team - Kristy Demmers, Nauman Maqbool, Michelle French, Shirley Martin and Fatima Barragan – to the International Society of Animal Genetics in Edinburgh in July.

The research will use a comparative genomic framework to identify the key genes involved in placental development and function. Some new genomic resources will be used from the platypus, opossum, wallaby and 17 placental mammals.

Abnormalities in placental development are associated with early pregnancy failures and although it has been acknowledged that there is likely to be a genetic cause, few candidate genes have so far been identified.

Knowledge of the relevant genes would provide useful targets for the further study of the genetic basis of variability in placentation and the growth and survival of the foetus.

The placenta is a crucial organ, facilitating nutrient and gas exchange between the mother and foetus, altering maternal physiological conditions to sustain pregnancy, while also protecting the foetus from the maternal immune system.

Contacts

Email Neil Gemmell at for more information.

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